Salmon Sperm Facial in Los Angeles: What It Actually Is, What It Costs and Whether It Works

By Nurse Jamie (Jamie Sherrill, RN) | Medically reviewed by Jamie Sherrill, RN | Last updated September 11, 2026

If you have seen "salmon sperm facial" all over TikTok and wondered whether it is a joke, it is not. It is the viral nickname for one of the most requested K-beauty treatments in Los Angeles right now, and it has been reported that celebrities including Jennifer Aniston and Kim Kardashian have tried it. The real name is PDRN, a purified DNA fragment derived from salmon, and the best-known brand is Rejuran. At Beauty Ranch Medical Spa in Brentwood, we have been offering Rejuran PDRN since before it went viral. Nurse Jamie traveled to Seoul, where Rejuran was developed, to study how PDRN and K-beauty treatments are done at the source, and brought that protocol back to Los Angeles. Today we offer more ways to receive the salmon sperm facial than any other facility in Los Angeles: classic microneedling, the Potenza Fusion tip, Potenza RF microneedling, or the painless Alma TED facial add-on.

This guide covers what a salmon sperm facial is, how it works, what it costs in Los Angeles, what results to expect, and how it compares to other skin boosters.

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What Is a Salmon Sperm Facial?

A salmon sperm facial is a skin treatment that uses PDRN, short for polydeoxyribonucleotide, a fragment of DNA extracted and purified from salmon. Salmon DNA is used because it is structurally very similar to human DNA, which lets the skin recognize and use it without an immune reaction. There is no actual sperm in the product, and nothing about the treatment is fishy in the room. The nickname stuck because the DNA is sourced from salmon reproductive cells, and because "salmon sperm" gets clicks.

The treatment originated in South Korea, where PDRN has been used medically for wound healing for years before making its way into aesthetics. It is now one of the core K-beauty treatments in Los Angeles clients ask us about, alongside XERF, Titanium Lifting and exosomes.

Salmon Sperm Facial vs Salmon DNA Facial vs Rejuran vs PDRN

These all describe the same thing at different levels of precision:

• PDRN is the active ingredient, the purified salmon DNA fragment.
• Rejuran is the best-known Korean brand of PDRN skin booster and the one we use at Beauty Ranch.
• Salmon DNA facial is the polite nickname.
• Salmon sperm facial is the viral nickname.
• Polynucleotides or PN is the broader category of DNA-based skin boosters you may see in UK and European clinics.

If you have been searching for any of these, you are looking for the same treatment. For a deeper dive on the science, read our Rejuran PDRN guide.

How Does a Salmon Sperm Facial Work?

PDRN works differently from fillers and from hyaluronic acid boosters. Instead of adding volume or water, it signals your skin to repair itself. When PDRN reaches the dermis it binds to receptors that trigger cell regeneration, calms inflammation and stimulates fibroblasts, the cells that make collagen and elastin. Over the following weeks the skin becomes thicker, smoother, more hydrated and more even in tone.

That is why PDRN is often described as a "skin healer" rather than a plumper. The results are your own skin functioning better, not a product sitting under the surface.

Four Ways We Do the Salmon Sperm Facial at Beauty Ranch

Topical PDRN serums and creams are trending too, but PDRN molecules are too large to pass through intact skin on their own. To get real results, the product has to get into the dermis. Most clinics offer one delivery method. At Beauty Ranch you can choose from four, and we will recommend the right one for your skin, your tolerance for downtime and your goals.

Option 1: Classic Microneedling With Rejuran

Traditional microneedling creates thousands of micro-channels in the skin, and the Rejuran PDRN is applied during the pass so it is driven straight into them. This is the most accessible option and a great fit if you are already doing a microneedling series. Expect 24 to 48 hours of pinkness. See our microneedling in Los Angeles page.

Option 2: Potenza Fusion Tip With Rejuran Infused During (RF Off)

The Potenza Fusion tip is built for infusing product. With this treatment the radiofrequency stays off, and as the microneedles create their channels, a chamber in the tip pushes air that drives the Rejuran PDRN directly into the skin during the pass. It is the most efficient way to get PDRN into the dermis and is the option most clients mean when they ask for the Korean-style salmon sperm facial. Expect 24 to 48 hours of pinkness. Learn more about Potenza microneedling in Los Angeles.

Option 3: Potenza RF Microneedling With Rejuran Applied After

Our most powerful skin tightening option. With the standard Potenza tip, radiofrequency energy heats the dermis through insulated microneedles to stimulate collagen and tighten skin. Because radiofrequency cannot be performed on wet skin, the Rejuran is not applied during this pass. As soon as the RF microneedling is complete, we apply the Rejuran PDRN onto the freshly opened channels so it absorbs while the skin is most receptive. You get RF tightening and PDRN regeneration in one visit. Expect 24 to 48 hours of pinkness. Learn more about Potenza RF microneedling in Los Angeles.

Option 4: The Painless, Needle-Free Alma TED Facial Add-On

For clients who want zero needles, zero pain and zero downtime, we deliver Rejuran PDRN with Alma TED, an ultrasound-based technology that uses acoustic sound waves and air pressure to open the skin's pathways and push the PDRN into the dermis without breaking the surface. It is offered as an add-on to any Beauty Ranch facial, so you can turn a Signature Hydrating facial or Diamond Glow into a salmon sperm facial in the same visit. The treatment feels like a gentle vibrating massage, there is no numbing, no redness and no marks, and you can put makeup on and go straight back to your day. It is ideal for sensitive skin, for clients who cannot tolerate needles, and as a maintenance option between microneedling sessions. Alma TED is the same technology we use for hair restoration; see our Alma TED in Los Angeles page.

Call to Book the TED Add-On: (310) 587-3502

Which Option Is Right for You?

• Want the classic Korean-style infusion and maximum PDRN absorption: Potenza Fusion tip, RF off, Rejuran infused during.
• Want skin tightening plus PDRN in one visit and are fine with a day or two of pinkness: Potenza RF microneedling, Rejuran applied after.
• Want a solid result at a simpler price point: classic microneedling with Rejuran.
• Want a completely painless option with no needles and no downtime, or have very reactive skin: Alma TED.
• Doing a series: many clients alternate Potenza and TED sessions.

Under-Eye Treatment

The thin skin under the eyes responds especially well to PDRN, which is why Rejuran is popular for crepey under-eye skin, fine lines and dark circles that come from thinning skin rather than pigment. Ask about under-eye treatment at your consultation.

What a Salmon Sperm Facial Treats

• Fine lines and early wrinkles, especially around the eyes and mouth
• Dull, dehydrated or "tired" looking skin
• Rough texture and enlarged pores
• Acne scarring and post-acne marks
• Thinning, crepey skin on the face, neck and under eyes
• Redness and sensitivity, because PDRN is anti-inflammatory
• Skin that needs a reset after sun damage or GLP-1 weight loss

It is a good fit for clients in their late 20s and up who want their skin quality to improve rather than their features to change.

What the Treatment Is Like

For classic microneedling and the Potenza Fusion tip, the Rejuran PDRN is delivered during the pass. For Potenza RF microneedling, the RF pass is completed first and the Rejuran is applied immediately afterward, since radiofrequency cannot be used on wet skin. In every case a final layer is applied before you leave. The whole appointment is about an hour.

For Alma TED, there is no numbing. After cleansing, the PDRN is applied and the TED handpiece glides over the skin for about 20 minutes with a gentle vibration and warmth. The appointment is about 30 to 40 minutes.

Downtime and Aftercare

With microneedling or Potenza, expect pinkness and mild swelling, similar to a sunburn, for 24 to 48 hours. Tiny pinpoint marks can be visible for a day. Most clients go back to work the next day. For the first 24 hours, avoid makeup, sweating, heat and active skincare, and use only the post-treatment products we send home with you.

With Alma TED there is no downtime. Skin may look slightly flushed for an hour. You can apply makeup and return to normal activities immediately.

Daily SPF 50 is required after every option.

Salmon Sperm Facial Results: Before and After

Skin looks hydrated and glowy within a few days as the initial redness fades. The real change shows at four to six weeks as new collagen and elastin build. Texture smooths, pores tighten, fine lines soften and the overall tone evens out. For lasting change we recommend a series of three sessions spaced about four weeks apart, then maintenance one to two times a year.

Before and after photos of our Rejuran PDRN clients are available in the studio at your consultation.

How Much Does a Salmon Sperm Facial Cost in Los Angeles?

If you want the official viral brand, the one brought over from Korea, the Rejuran add-on is $600 at Beauty Ranch. That is the PDRN itself, added to the delivery method you choose: classic microneedling, the Potenza Fusion tip, Potenza RF microneedling, or the painless Alma TED facial add-on. Other PDRN options are available, so call (310) 587-3502 to check what fits your skin and your budget.

What Affects the Total Price

• Delivery method. Potenza RF microneedling adds radiofrequency collagen stimulation and skin tightening on top of the PDRN; classic microneedling is the simpler option; Alma TED is added to the facial you choose.
• Single session vs series. Three sessions about four weeks apart is the standard protocol, and series plans are priced differently than a single visit.
• Treatment area. Face only vs face plus neck or under eyes.
• Product amount. Larger areas need more PDRN.

Call (310) 587-3502 or book a consultation and we will map out the plan and the price together.

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Salmon Sperm Facial vs Other Skin Boosters

• Rejuran PDRN vs SkinVive. SkinVive is a hyaluronic acid microdroplet injectable that adds hydration and glow for about six months. Rejuran regenerates the skin itself. Many clients do both. See our Sculptra and SkinVive guide.
• Rejuran PDRN vs exosomes. Exosomes are growth-factor signaling vesicles that speed healing; PDRN is a DNA fragment that triggers repair. They are complementary and we often stack them after Potenza.
• Rejuran PDRN vs Sculptra. Sculptra is a biostimulator injected deeper to build volume over months. Rejuran improves surface quality. Different jobs.
• Rejuran PDRN vs Profhilo. Profhilo is a hyaluronic acid booster popular in the UK that is not FDA approved in the US. Rejuran and SkinVive are the closest approved alternatives.

For a full comparison, read our injectable biostimulators and skin boosters guide.

What the Research Shows

PDRN is not just a TikTok trend. It has been used in medicine for wound healing and tissue repair for decades, and there is a growing body of peer-reviewed research behind its use in skin. A 2017 review in Frontiers in Pharmacology (Squadrito et al., "Pharmacological Activity and Clinical Use of PDRN") summarizes how PDRN activates the adenosine A2A receptor to stimulate tissue regeneration, increase collagen and reduce inflammation. A 2022 review in the Chinese Journal of Plastic and Reconstructive Surgery (Khan et al., "Polydeoxyribonucleotide: A promising skin anti-aging agent") concluded that PDRN improves skin elasticity, hydration and wrinkle depth with a strong safety profile. Korean clinical studies on Rejuran specifically have reported improvements in skin texture, pore size and fine lines after a series of treatments.

The honest caveat: most of the aesthetic studies are small, and results depend heavily on getting the PDRN into the dermis, which is why delivery method matters so much.

Do Salmon DNA Serums and Creams Work?

PDRN skincare has exploded, and topical products can support hydration and barrier repair. But PDRN is a large molecule that cannot pass through intact skin on its own, so a serum will never match an in-office treatment where the PDRN is delivered into the dermis with microneedling, Potenza or TED. Think of topical PDRN as maintenance between treatments, not a replacement for them.

Why Beauty Ranch Is the Best Place in Los Angeles for a Salmon Sperm Facial

• Four delivery methods, not one, including a painless option. Most Los Angeles clinics offer PDRN with microneedling only. We offer classic microneedling, the Potenza Fusion tip, Potenza RF microneedling, or the painless Alma TED facial add-on, so the treatment fits you instead of the other way around.
• Trained at the source. Nurse Jamie traveled to Seoul, where Rejuran was developed, to study how Korean clinics perform PDRN treatments, and built our protocol on what she learned.
• Celebrity-trusted expertise. Nurse Jamie is a registered nurse with more than two decades in aesthetics and the founder of the Nurse Jamie skincare brand used by celebrities and their teams.
• The official brand, priced up front. The Rejuran add-on is $600, so you know what the real Korean PDRN costs before you walk in. Other PDRN options are available; call to check.
• Stack it with the rest of our K-beauty menu. XERF, Titanium Lifting, exosomes and Rejuran can be combined into one treatment plan. See our K-beauty treatments in Los Angeles guide.
• Minutes from Santa Monica, Pacific Palisades and Beverly Hills. Our Brentwood location at 140 South Barrington Place serves the whole Westside.

Is the Salmon Sperm Facial Safe?

PDRN has a long safety record in medicine and is well tolerated in the skin because the DNA fragments are structurally similar to our own. Side effects are limited to temporary redness, swelling and pinpoint marks from microneedling. It is not recommended if you are pregnant or breastfeeding, have an active skin infection in the area, or have a fish allergy, which we will screen for at your consultation.

Frequently Asked Questions

Is salmon sperm good for your face?

Purified salmon DNA (PDRN) is one of the best-studied regenerative ingredients in aesthetics. It stimulates collagen, calms inflammation and improves skin texture and hydration. The results come from your own skin repairing itself.

How much does a salmon sperm facial cost?

At Beauty Ranch, the Rejuran add-on is $600 if you want the official viral brand from Korea, added to classic microneedling, the Potenza Fusion tip, Potenza RF microneedling, or the painless Alma TED facial add-on. Other PDRN options are available at different price points; call (310) 587-3502 to check.

Does Jennifer Aniston use salmon sperm facials?

Jennifer Aniston has said in interviews that she tried a salmon sperm facial, and Kim Kardashian has been shown getting one on her show. Celebrity interest is a big part of why the treatment went viral.

How long does a salmon sperm facial last?

Results from a series of three typically last six to twelve months. Maintenance sessions once or twice a year keep skin quality up.

Is a salmon sperm facial the same as Rejuran?

Yes. Rejuran is the leading brand of PDRN, and "salmon sperm facial" and "salmon DNA facial" are nicknames for PDRN treatments.

Does a salmon sperm facial hurt?

No. For microneedling or Potenza we apply topical numbing first, so most clients feel pressure and warmth rather than pain. With Alma TED there are no needles at all; it feels like a warm vibrating massage.

What is the difference between the Potenza Fusion tip and Potenza RF for the salmon sperm facial?

They are two different treatments. With the Fusion tip, radiofrequency stays off and the tip's air chamber infuses the Rejuran into the skin during the microneedling pass. With Potenza RF, the radiofrequency is on for skin tightening and the Rejuran is applied right after the pass, because RF cannot be performed on wet skin. Your provider will recommend one based on whether your priority is PDRN absorption or tightening.

Is there a painless salmon sperm facial?

Yes. Beauty Ranch offers a painless, needle-free version using Alma TED ultrasound technology, added to any of our facials. It pushes the PDRN into the skin with sound waves and air pressure. No numbing, no redness, no downtime. Call (310) 587-3502 to book it.

Do salmon DNA serums work as well as the facial?

No. Topical PDRN can help hydration and barrier repair, but the molecule is too large to pass through intact skin. In-office delivery with microneedling, Potenza or TED is what gets PDRN into the dermis where it works.

Who performs the salmon sperm facial at Beauty Ranch?

Treatments are performed under the direction of Nurse Jamie (Jamie Sherrill, RN), who studied PDRN treatments in Seoul, South Korea, and her team of licensed providers.

Is there actual sperm in the treatment?

No. PDRN is a purified DNA fragment extracted from salmon. It is sterile, odorless and contains no cells.

What is the downtime?

With microneedling or Potenza, about 24 to 48 hours of pinkness and mild swelling. With Alma TED, none.

Can the salmon sperm facial be done under the eyes?

Yes. Under-eye treatment is one of the most popular uses of Rejuran because PDRN thickens and smooths thin, crepey skin.

Where can I get a salmon sperm facial near Brentwood or Santa Monica?

Beauty Ranch Medical Spa is at 140 South Barrington Place in Brentwood, Los Angeles, minutes from Santa Monica, Pacific Palisades and Westwood. Call (310) 587-3502 or book online.

Book a Salmon Sperm Facial in Brentwood, Los Angeles

Beauty Ranch Medical Spa was offering Rejuran PDRN before it had a viral nickname. Book a consultation at 140 South Barrington Place, Brentwood. Open Monday through Saturday 9 to 5 and Sunday 9 to 4. Call (310) 587-3502 or book online.

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Related reading

• Rejuran in Los Angeles: The K-Beauty Skin Healing Treatment
• Rejuran PDRN Salmon DNA Facial Explained
• K-Beauty Treatments in Los Angeles
• Potenza RF Microneedling in Los Angeles
• Injectable Biostimulators and Skin Boosters Guide

Rejuran PDRN can also be added to a facial at Beauty Ranch. See all of our facials in Brentwood, Los Angeles and the add-ons available with each one.